Author's response to reviews Title: Class III beta-tubulin is a predictive marker for taxane-based chemotherapy in recurrent and metastatic gastric cancer Authors:
نویسندگان
چکیده
Jun-Eul Hwang ([email protected]) Ji-Yun Hong ([email protected]) Karham Kim ([email protected]) Seung-Hun Kim ([email protected]) Won-Young Choi ([email protected]) Min-Jee Kim ([email protected]) Sung-Hoon Jung ([email protected]) Hyun-Jeong Shim ([email protected]) Woo-Kyun Bae ([email protected]) Eu-Chang Hwang ([email protected]) Kyung-Hwa Lee ([email protected]) Jae-Hyuk Lee ([email protected]) Sang-Hee Cho ([email protected]) Ik-Joo Chung ([email protected])
منابع مشابه
Class III beta-tubulin expression in tumor cells predicts response and outcome in patients with non-small cell lung cancer receiving paclitaxel.
Both fundamental and clinical studies suggest that class III beta-tubulin expression is associated with resistance to taxanes and constitutes a prognostic factor in several solid tumors. In this study, we assessed the prognostic and predictive value of class III beta-tubulin in tumors of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) treated with paclitaxel-base...
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Background: Gastric cancer is an important health problem across the world. Chemotherapy in combination with local treatment is standard treatment for locally advanced gastroesophageal cancers. The purpose of this investigation was evaluation of response and tolerability to neoadjuvant EOX regimen in locoregionally advanced gastric cancer. Materials and Methods: patients with locoregionally adv...
متن کاملAnalysis of Beta-Tubulin Gene Exon 4 Mutations in Advanced Stage III or IV Gastric Cancer
The mechanisms that cause chemoresistance of gastric cancer have yet to be elucidated. Taxanes and promising agents that were recently approved for treatment of advanced or recurrent gastric cancer. Mutations of beta-tubulin, which is a target of taxianes, have been shown to confer chemoresistance against these agents. The aim of the present study is to investigate the presence of mutations of ...
متن کاملExpression of class III beta-tubulin in colorectal carcinomas: an immunohistochemical study using TU-20 & TuJ-1 antibody.
BACKGROUND & OBJECTIVE Expression of class III beta-tubulin represents newly discovered marker of resistance to taxol-based chemotherapy in a wide spectra of carcinomas. However, very little is known about its expression in colorectal carcinomas. This study was done to determine class III beta-tubulin expression in a large series of colonic carcinomas, covering tumours with different degree of ...
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Title: Impact of modern chemotherapy on the survival of women presenting with de novo metastatic breast cancer
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